Testing menopausal hormone levels: Is it necessary?

Correcting for multiple-testing in multi-arm trials: is it necessary and is it done?

BACKGROUND Multi-arm trials enable the evaluation of multiple treatments within a single trial. They provide a way of substantially increasing the efficiency of the clinical development process. However, since multi-arm trials test multiple hypotheses, some regulators require that a statistical correction be made to control the chance of making a type-1 error (false-positive). Several conflicti...

Is It Necessary to Restrict Forex Financial Trading? A Modified Model

The Central Bank of Iran banned online currency trading through Forex brokers in November 2016. However, some Iranian speculators still trade in the online Forex market. Is this prohibition on Forex trading reasonable? According to reports, the majority of Forex day traders fail and leave the market within six months to a year. Some scholars attribute this failure to the changeable characterist...

Short stay in general intensive care units: is it always necessary?

  Background: There are challenges ahead of short-term hospitalization of low-risk patients hospitalized only for monitoring of severe disease who may die soon after admission. The purpose of this study was to suggest strategies for the management of ICU stay lengths and to ensure optimal use of ICU resources.   Methods: The study was conducted retrospectively on 246 patients admitted to 9 gene...

Match Necessary ? Is It Possible ?

Pathology: is it still necessary?

One may wonder what may be the reasons to ask this apparently odd question. Undoubtedly, the main concern is that we are still far away from being able to precisely identify the target population of patients for tailored interventions. It has been repeatedly shown by the results of large clinical trials that the benefit of new therapeutic approaches is relatively small, and that it is most like...